2022 iTHRIV Pilot: Acquiring Hyperpolarized 129Xe Magnetic Resonance Images of Lung Ventilation
The purpose of this study is to identify early stages of lung rejection occurring after lung transplant. Another purpose is to gather information about rejection in order to help develop and test procedures for detecting lung rejection.
For this study, the phenotypes of Chronic Lung Allograft Dysfunction (CLAD) encompass a range of pathologies that cause a transplanted lung to not achieve or maintain normal function. CLAD is manifested as airflow restriction and/or obstruction and is predominantly a result of chronic rejection, which are differentiated by immunophenotyping of their peripheral blood and lung tissues from bronchoscopy. Our ability to detect the immunophenotyping specific to BOS CLAD or R-CLAD will be significantly enhanced by hyperpolarized gas MRI (HGMRI)-guided bronchoscopy. MRI with hyperpolarized xenon gas is a new medical imaging technique that can show where the air goes in your lungs when you breathe and how your lungs are catching oxygen from air and moving oxygen into the blood. Our idea is that by using this new MRI imaging, parts of the lung with lung rejection-like abnormalities can be found so that transplant doctors can sample those specific areas of the lung during the bronchoscopy.
PUBLICATION: Garrison WJ, Mugler JP 3rd, Mata JF, Nunoo-Asare RN, Shim YM, Miller GW. Acquiring Hyperpolarized 129Xe Magnetic Resonance Images of Lung Ventilation. J Vis Exp. 2023 Nov 21;(201). doi: 10.3791/65982. PMID: 38078603.| Keywords | medical imaging, chronic lung allograft dysfunction, lung tissues, immunophenotyping, hyperpolarized gas mri, lung abnormalities detection, hgmri, ithriv pilot, lung rejection, clad, hyperpolarized xenon gas, bronchoscopy, lung transplant |
| Storage Organization | University of Virginia |
| Partner Institution(s) | University of Virginia |
| Funding Source(s) | NCATS Award UL1TR003015 iTHRIV CTSA |